Premium
Evaluation of Fibrosis in the Disse Space in Noncirrhotic Alcoholic Liver Disease
Author(s) -
Robert Philippe,
Champigneulle Bruno,
Kreher Isabelle,
Gueant JeanLouis,
Foliguet Bernard,
Dollet JeanMarc,
Bigard MarcAndré,
Gaucher Pierre
Publication year - 1989
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1989.tb00306.x
Subject(s) - perisinusoidal space , medicine , gastroenterology , liver biopsy , hepatic fibrosis , fibrosis , pathology , portal venous pressure , vein , biopsy , cirrhosis , portal hypertension , chemistry , hepatocyte , biochemistry , in vitro
In 40 alcoholic noncirrhotic patients, we performed a fiver biopsy and determined the wedged hepatic vein pressure, the free hepatic vein pressure, and the intrahepatic vein pressure. In 27 of them, the serum concentration of the N‐terminal peptide of type 111 procollagen (PIIIP) and of the laminin P1 fragment was measured. All the liver biopsies were studied by light and transmission electronic microscopy. A score of collagenization of the Disse space (six classes) was performed using transmission electronic microscopy. 37 of the 40 patients had pathological collagenization of the Disse space which was correlated with intrahepatic pressure (p < 0.01). The laminin P1 blood level in patients (1.38 ± 0.51 U/ml) was increased, compared to the values of our controls (0.99 ± 0.10 U/ml, p < 0.01) and was correlated with the wedge hepatic vein pressure (p < 0.01). The PlllP blood level was not significantly increased except when Mallory bodies were found in hepatocytes (p < 0.05). The laminin P1 blood level seemed to be a good biological marker for detection of liver fibrosis in long‐term alcoholic intake.