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Altered Ultrastructure of Lactating Rat Mammary Epithelial Cells Induced by Chronic Ethanol Ingestion
Author(s) -
Vilaró Senén,
Viñas Octavi,
Remesar Xavier
Publication year - 1989
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1989.tb00297.x
Subject(s) - acetaldehyde , ethanol , endocrinology , medicine , ultrastructure , secretion , mammary gland , chemistry , casein , golgi apparatus , ingestion , liquid diet , biology , biochemistry , cell , anatomy , cancer , breast cancer
The ethanol and acetaldehyde uptake by the lactating rat mammary gland as well as their effects on this gland at the ultrastructural level have been studied. The extraction of acetaldehyde was greater than that of ethanol both after chronic and acute ethanol treatment. Chronic ethanol administration resulted in a loss of the mammary cell polarization, in a reduction of the Golgi dictyosomal elements and in several abnormalities at the level of casein maturation and secretion, whereas lipid synthesis and secretion did not seem to be affected. Normal spherical casein micelles took on a filament‐like structure and casein vesicles appeared fused together forming ma‐crovesicles. All these alterations were specific of ethanol and/or acetaldehyde action and were not due to the associated malnutrition, as deduced from the lack of visible effects in the nutritional control group.