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Low Dose Alcohol Contracts the Human Umbilical Artery in Vitro
Author(s) -
SavoyMoore R. T.,
Dombrowski M. P.,
Cheng A.,
Abel E. A.,
Sokol R. J.
Publication year - 1989
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1989.tb00281.x
Subject(s) - alcohol , umbilical artery , in vitro , in vivo , artery , medicine , fetus , serotonin , anesthesia , cardiology , chemistry , pregnancy , biology , biochemistry , microbiology and biotechnology , genetics , receptor
Beginning at very low concentrations (0.001 g/100 ml), alcohol elicited dose‐dependent contractions of the human umbilical artery in vitro. Additionally, 16 of the 108 arteries tested had a 5‐10‐min spasm in response to alcohol. Alcohol (0.2 91100 ml) also increased tension developed in response to all angiotensin II doses, but had no effect on serotonin‐induced contractions. These results suggest that alcohol may increase umbilicoplacental resistance in vivo, thus decreasing fetal‐placental blood flow.