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Evidence of Increased Class I MHC Expression on Human Peripheral Blood Lymphocytes during Acute Ethanol Intoxication
Author(s) -
Kolber Michael A.,
Walls Ron M.,
Hinners Marion L.,
Singer Dinah S.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb01353.x
Subject(s) - immunology , antigenicity , major histocompatibility complex , antigen , immunity , immune system , population , histocompatibility , cellular immunity , biology , peripheral blood , human leukocyte antigen , medicine , environmental health
Certain ethanol‐related diseases in humans have been linked to disorders of immunity. Although humoral and cellular immunity have been studied, the precise mechanisms whereby ethanol use leads to tissue damage remain unknown. In order to explore the hypothesis that ethanol may lead to alteration in expression of tissue Class I major histocompatibility antigen causing an autoimmune phenomenon, a population of acutely ethanol‐intoxicated patients was studied. Measurement of Class I major histocompatibility antigen on peripheral blood lymphocytes in this population showed a highly significant ( p < 0.01) increase over controls. The role that this increased antigenicity may play in the evolution of clinical disease is discussed.