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Some Aspects of Antioxidant Status in Blood from Alcoholics
Author(s) -
Bjørneboe GunnElin Aa.,
Johnsen Jon,
Bjørneboe Anders,
Marklund Stefan L,
Skylv Nina,
Høiseth Arne,
BacheWiig JonErik,
Mørland Jørg,
Drevon Christian A.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb01350.x
Subject(s) - glutathione peroxidase , superoxide dismutase , medicine , vitamin e , antioxidant , tocopherol , endocrinology , catalase , placebo , vitamin , chemistry , gastroenterology , oxidative stress , biochemistry , pathology , alternative medicine
The effect of ethanol consumption on serum concentration of α‐tocopherol, erythrocyte activities of superoxide dismutase, glutathione peroxidase, and catalase were studied in 34 male alcoholics and 35 age‐matched controls. Serum concentration of α‐tocopherol was 30% lower in the alcoholics as compared to the controls ( p < 0.001). No significant difference was found in erythrocyte activities of Cu‐Zn‐containing superoxide dismutase, glutathione peroxidase, or catalase between the groups. Of the 12 alcoholics with subnormal serum α‐tocopherol, 50% had concomitant neurological clinical scores and cerebellar atrophy, and their neurological scores were significantly higher (82%) than for alcoholics with normal α‐tocopherol levels ( p < 0.03). However, no significant correlation was observed between levels of α‐tocopherol and neurological clinical scores or cerebellar atrophy. When entering the study, alcoholics and controls were each randomized into two separate groups, receiving vitamin E supplementation (100 mg/day) or placebo capsules for 10 days, respectively. In the four subgroups, α‐tocopherol levels increased only in alcoholics receiving vitamin E supplementation (23%) ( p < 0.001). The reduced serum levels of α‐tocopherol in alcoholics may be normalized by vitamin E supplementation.