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A Nonhypoglycemic Chlorpropamide Analog that Inhibits Aldehyde Dehydrogenase
Author(s) -
Nagasawa Herbert T.,
Elberling James A.,
Shirota Frances N.,
DeMaster Eugene G.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb00242.x
Subject(s) - chlorpropamide , aldehyde dehydrogenase , chemistry , aldehyde , biochemistry , medicine , endocrinology , enzyme , diabetes mellitus , catalysis
Chlorpropamide (CP), a sulfonylurea‐type oral hypoglycemic agent, is known to provoke a flushing reaction reminiscent of the disulfiram‐ethanol reaction in certain individuals. This is manifested in rodents by an increase in blood acetaldehyde levels after ethanol administration. When the sulfonamide N 1 ‐nitrogen of CP was substituted with an ethyl group, the product, N 1 ‐ethylchlorpropamide, was found to be three times as active as CP in raising ethanol‐derived blood acetaldehyde. However, whereas CP lowered fasting blood glucose in rats measured over 6 h, N 1 ‐ethylchlorpropamide was devoid of hypoglycemic activity, suggesting that the latter might be potentially useful as an alcohol deterrent agent.