Premium
Dose‐Additive Inhibition of Intake of Ethanol by Cholecystokinin and Bombesin
Author(s) -
Kulkosky Paul J.,
Glazner Gordon W.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb00194.x
Subject(s) - bombesin , cholecystokinin , ethanol , neuropeptide , chemistry , peptide , endogeny , saline , endocrinology , medicine , pharmacology , biochemistry , biology , receptor
Cholecystokinin (CCK) and bombesin (BBS) are neuropeptides of the brain and gut which have been shown to inhibit intake of ethanol. CCK octapeptide and BBS tetradecapeptide were injected intrapritoneally in both single doses and combinations of doses to determine Interactions of the two peptides in the control of consumption of ethanol. Water‐deprived rats were given access to 5% w/v ethanol for 30 min, followed by a 30‐min access to water, daily. One minute before presentation of ethanol, rats were injected with either saline or one of ten peptide solutions (three of CCK alone, three of BBS done, and four combinations of both). Results from the injections of single peptides were used to determine predicted inhibitions of the peptide combinations, assuming perfect additivity of doses. None of the actual values of inhibition of intake of ethanol by peptide combinations differed significantly from its predicted additive value. Endogenous CCK‐like and BBS‐like peptides may suppress intake of ethanol by an additive mechanism of inhibition.