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Calcium Status and Calcium‐Regulating Hormones in Alcoholics
Author(s) -
Bjørneboe GunnElin Aa.,
Bjørneboe Anders,
Johnsen Jon,
Skylv Nina,
MD Helge Oftebro,
M Gautvik Kaare,
Høiseth Arne,
Mørland Jørg,
Drevon Christian A.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb00185.x
Subject(s) - calcium , calcitonin , medicine , parathyroid hormone , endocrinology , alkaline phosphatase , vitamin d and neurology , hormone , chemistry , homeostasis , calcium metabolism , chronic alcoholic , magnesium , vitamin , phosphorus , enzyme , biochemistry , organic chemistry
To elucidate effects of chronic ethanol consumption on clinical chemical parameters reflecting overall calcium homeostasis 34 hospitalized male alcoholics and 35 age‐matched controls were studied during the winter season. Serum concentrations of 25‐hydroxyvitamin D, and 1,25‐dihydroxyvitamin Ds were reduced by 28% ( p < 0.01) and 24% ( p < 0.02) among the alcoholics as compared to the controls, respectively. Dietary intake of vitamin D 3 did not differ significantly between the groups. The calcium level was below lower limit of reference in nine alcohdics (26%). Serum concentrations of parathyroid hormone and phosphorus were within normal ranges in both groups, and no differences were observed in levels of magnesium, vitamin D‐binding protein, calcitonin, or alkaline phosphatase. In conclusion, it is possible that the activities of enzymes crucial in vitamin D 3 metabolism may be altered in alcoholics.