Premium
Effects of Long‐Term Ethanol Inhalation on the Immune and Hematopoietic Systems of the Rat
Author(s) -
Marietta Cheryl A.,
Jerrells Thomas R.,
Meagher Richard C.,
Karanian John W.,
Weight Forrest F.,
Eckardt Michael J.
Publication year - 1988
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1988.tb00182.x
Subject(s) - haematopoiesis , spleen , bone marrow , ethanol , immune system , hemoglobin , progenitor cell , granulocyte , immunology , inhalation , medicine , white blood cell , endocrinology , blood cell , red blood cell , chemistry , pharmacology , biology , stem cell , biochemistry , anesthesia , microbiology and biotechnology
An inhalation method of ethanol administration was used to study the effects of 14 day, of ethanol administration on the immune and hematopoietic systems of the rat. A decrease in cellularity was found in the spleen, thymus, and bone marrow of ethanol‐treated rats. Although the red blood cell count, white blood cell count, and hemoglobin concentration were not significantly different between treatment and control groups, treatment with ethanol altered the relative proportion of lymphocytes and polymorphonuclear leukocytes in the peripheral blood. The granulocyte‐macrophage progenitor cells in the bone marrow were unaffected by ethanol treatment, but a significant decline in the number of erythroid progenitor cells warn noted in ethanol‐treated rats. Splenic lymphocytes, although fewer in number in the ethanol‐treated rats, showed no significant difference in ability to proliferate when stimulated by nonspecific mitogens