Premium
Carbohydrate‐Deficient Transferrin in Serum in Patients with Liver Diseases
Author(s) -
Stibler Helena,
Hultcrantz Rolf
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb01925.x
Subject(s) - carbohydrate deficient transferrin , transferrin , radioimmunoassay , gastroenterology , medicine , steatosis , alcohol abuse , liver disease , liver biopsy , fatty liver , alcohol consumption , endocrinology , alcohol , disease , biopsy , chemistry , biochemistry , psychiatry
Carbohydrate‐deficient transferrin (CDT) in serum was analyzed by isocratic microanion exchange chromatography at pH 5.65 followed by a transferrin radioimmunoassay in 102 patients with biopsy‐verified liver diseases. CDT values were normal in all of the 87 nonalcohol‐abusing patients irrespective of type or degree of liver disease. Thirteen of the 15 alcoholic patients (87%) with current abuse showed elevated CDT values while in abstaining alcoholics with remaining liver disease the values were normal. No correlations were found between CDT level and volume density of liver fibrosis or steatosis or values of a number of clinicochemical liver tests. The only significant correlation demonstrated was between CDT concentration and the level of present daily alcohol consumption in the alcoholic patients. These results indicate that CDT can be used as a marker of present but not previous alcohol abuse, even in patients with various liver diseases.