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Discordance between the Cortisol Response to Insulin‐Hypoglycemia and 30‐Minute ACTH Stimulation Test in Chronic Alcoholic Men
Author(s) -
Knudsen G. Moos,
Christensen H,
Berild D,
Melgaard B,
Kirkegaard C,
Hasselbalch H
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb01318.x
Subject(s) - hypoglycemia , medicine , insulin tolerance test , endocrinology , insulin , stimulation , chronic alcoholic , acth stimulation test , adrenocorticotropic hormone , atrophy , hormone , insulin resistance , insulin sensitivity
An insulin hypoglycemia test and a 30‐min ACTH stimulation test was performed in 10 chronic alcoholic men, who had been abstinent from alcohol for at least one month. Attenuated serum cortisol responses were found in six of the patients despite a normal ACTH test. Four patients showed normal responses to both the insulin hypoglycemia test and the short ACTH test. No correlation was demonstrated between the cortisol response and the severity of alcoholism, cerebral atrophy, and peripheral neuropathy. It is concluded that in chronic alcoholism the short ACTH test may fail in disclosing hypofunction of the integrated hypothalamic‐pituitaryad‐renocortical (HPA) axis as assessed with the insulin hypoglycemia test.