Premium
Neuroendocrine, Psychophysiological and Subjective Reactivity to an Alcohol Placebo in Male Alcoholic Patients
Author(s) -
Dolinsky Zelig S,
Morse David E,
Kaplan Richard F,
Meyer Roger E,
Corry Douglas,
Pomerleau Ovide F
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb01311.x
Subject(s) - placebo , alcohol , anxiety , alcohol consumption , psychology , medicine , cue reactivity , endocrinology , alcohol intake , clinical psychology , psychiatry , craving , addiction , biology , biochemistry , alternative medicine , pathology
Alteration in neuroendocrine activity associated with the regulation of energy metabolism and food intake may play a role in characterizing the alcohol dependent state. Alcoholics, when compared to controls, demonstrated significantly larger and more rapid glucose and insulin responses following the consumption of a placebo beer, which they believed contained alcohol. The existence of significant correlations between peak neuroendocrine responses and desire to drink, anxiety, as well as psychophysiological responses in alcoholics suggests the potential multivariate nature of the biological/behavioral state associated with alcohol dependence.