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Effects of Alpha‐Methylparatyrosine on Voluntary Consumption of Ethanol, Water, and Solid Food in UChA and UChB Rats
Author(s) -
Contreras Selfa,
Alvarado Rosa
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb01296.x
Subject(s) - ethanol , chemistry , food intake , food science , food consumption , alpha (finance) , turnover , water consumption , tyrosine hydroxylase , endocrinology , medicine , biochemistry , biology , enzyme , surgery , economics , construct validity , management , agricultural economics , patient satisfaction , engineering , waste management
The effect of daily doses of 80 mg/kg (intraperitoneal) of alphamethylparatyrosine, AMPT (inhibitor of tyrosine hydroxylase) on the voluntary consumption of ethanol, water, and solid food was studied in rats of both sexes belonging to the UChA (lower ethanol consumer) and UChB (high ethanol consumer) strains. The consumptions during the treatment period were compared to those of the preceeding one (basic). Decrease of ethanol and solid food intake and increase of that of water in UChB rats and only a decrease of solid food intake in UChA rats were observed. These effects cannot be ascribed to blocking of dopaminergic or noradrenergic synapses, since this dose of AMPT inhibits the in vivo synthesis of both catecholamines.