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Neuroglial and Neuroblastoma Cell Lines Are Capable of Metabolizing Ethanol Via an Alcohol‐Dehydrogenase‐Independent Pathway
Author(s) -
Wickramasinghe S. N.
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb01295.x
Subject(s) - alcohol dehydrogenase , ethanol , alcohol , neuroblastoma , chemistry , aldehyde dehydrogenase , enzyme , biochemistry , cell culture , biology , genetics
Two neuroglial cell lines (U‐251 MG and C6) had a substantial capacity to convert ethanol to acetate in vitro largely by an alcohol dehydrogenase (ADH)‐independent mechanism and three neuroblastoma cell lines (IMR‐32, NB41A3, and Neuro‐2a) had a lesser but significant ethanol‐metabolizing capacity which was also either partly or largely ADH‐independent. The ADH‐independent pathway of ethanol metabolism by neural cells appeared to be dependent on one or more isoenzymes of cytochrome P‐450. The data emphasize the possibility that the neurotoxicity of ethanol may be related to a relatively high ethanol‐metabolizing capability of neural tissue and particularly of neuroglial cells.