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Urinary Dolichol—A New Marker of Alcoholism
Author(s) -
Roine Risto P.,
Turpeinen Ursula,
Ylikahri Reino,
Salaspuro Mikko
Publication year - 1987
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1987.tb00166.x
Subject(s) - urinary system , dolichol , urine , creatinine , medicine , alcohol , chronic alcoholism , gastroenterology , chemistry , biochemistry , enzyme , biosynthesis
Urinary dolichol levels of 31 skid‐row alcoholics and 49 alcoholics entering a detoxification unit were compared to those of 51 nonalcoholic controls (social drinkers). The mean urinary dolichol content as related to urinary creatinine was significantly ( p < 0.001) higher in the two groups of alcoholics than in the controls. In this material the sensitivity of increased urinary dolichol in the detection of alcoholism was 68% as compared to 44% sensitivity of serum γ‐glutamyltransferase. The percentage of false‐positives in the control group was 3.9%. Urinary dolichol is suggested as a potential tool for the detection and follow‐up of alcohol abuse.