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Quantification of Physiological and Behavioral Measures of Alcohol Withdrawal in Long‐Sleep and Short‐Sleep Mice
Author(s) -
Gilliam David M.,
Collins Allan C.
Publication year - 1986
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1986.tb05166.x
Subject(s) - alcohol , abstinence , alcohol withdrawal syndrome , alcohol dependence , heart rate , sleep (system call) , respiration , psychology , blood alcohol , moro reflex , anesthesia , medicine , physiology , blood pressure , reflex , psychiatry , poison control , chemistry , injury prevention , biochemistry , environmental health , computer science , anatomy , operating system
A quantitative, muttMtmeneional animal model of the alcohol withdrawal syndrome is desirable for investigating individual differences in susceptibility to alcohol dependence. Following exposure to control or ethanoi diets for 7 or 14 days, we measured respiration rates, body temperature, acoustic startle responses, and heart rates in Long‐Steep (LS) and Short‐Sleep (SS) mice to determine how initial alcohol sensitivity influences dependence liability. SS mice consumed a greater amount of ethanoi diet and exhibited a more severe withdrawal syndrome than LS mice. Withdrawal severity resulted from an interaction of genotype with duration of ethanoi exposure. The abstinence syndrome was generally characterized by depressed behavioral and physiological functioning for both mouse lines. Initial alcohol sensitivity influenced the rate of alcohol increase in the blood during dependence induction which, in turn, influenced withdrawal severity. This model incorporates several discriminative measures that independently assess withdrawal reactions and provides a useful animal model of alcohol withdrawal.