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Reduced Sensitivity of Red Blood Cell (Na + , K + )‐ATPase to Ethanol in Vitro in Male Alcoholic Patients: Relationship to Clinical Characteristics
Author(s) -
Swann Alan C.,
Reilly Edward,
Overall John E.
Publication year - 1986
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1986.tb05136.x
Subject(s) - ethanol , anxiety , depression (economics) , medicine , red blood cell , atpase , alcohol , in vitro , gastroenterology , endocrinology , psychiatry , psychology , chemistry , enzyme , biochemistry , economics , macroeconomics
We examined red Wood ceil (Na + , K + )‐ATPase, its sensitivity to inhi‐brtion by ethanol in vitro, and its relationship to clinical characteristic! and history in 41 newly admitted alcoholic patients and 14 age‐matched healthy controls. Sensitivity to ethanol was significantly lower in the alcoholic patients and correlated negatively with ethanol intake. In addition, sensitivity of enzyme to ethanol was lower ir patients with high agitation‐anxiety ratings and correlated negatively with agitation and anxiety scores on the Brief Psychiatric Rating Scale. There were no relationships between (Na + , K + )‐ATPase measures and depressive symptoms, history of treatment for depression, or family history of depression. These data suggest that tolerance to the effects of ethanol on (Na + , K + )‐ATPase occurs in man and may be related to the severity of ethanol dependence or withdrawal.