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The Effect of Ethanol Intake on Propoxyphene Absorption and Biotransformation in Dogs
Author(s) -
Olsen H.,
Aune H.,
Lilleaasen P.,
Gulliksen M.,
Bodd E.,
Mwland J.
Publication year - 1986
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1986.tb05111.x
Subject(s) - biotransformation , propoxyphene , ethanol , pharmacology , absorption (acoustics) , chemistry , medicine , biochemistry , analgesic , materials science , enzyme , composite material
The effect of ethanol (0.5 and 1.0 g/kg) on gastrointestinal absorption and presystemic biotransformation of propoxyphene (4 mg/kg) was studied in dogs in a crossover design. Low ethanol doses (0.5 g/kg) had no effect on the bioavailability of propoxyphene. High ethanol doses (1.0 g/kg) enhanced the bioavailability of orally administered propoxyphene significantly (p < 0.05). With this dose of ethanol, the area under the blood concentration versus time curve (AUC) 0–5 h of propoxyphene was approximately 200% of the control value. The level of norpropoxyphene, a major metabolite of propoxyphene, was significantly decreased (p < 0.05) after administration of high ethanol doses. In all blood samples, after propoxyphene administration, an unidentified metabolite of propoxyphene was found, which formation was dose dependentJy inhibited by ethanol.