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Effects of Acute and Chronic Ethanol Exposure on the Response of Rat Aorta to a Thromboxane Mimic, U46619
Author(s) -
Karanian John,
Salem Norman
Publication year - 1986
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1986.tb05067.x
Subject(s) - thromboxane , chemistry , thromboxane a2 , ethanol , ex vivo , endocrinology , medicine , aorta , in vivo , thoracic aorta , in vitro , biochemistry , biology , receptor , platelet , microbiology and biotechnology
The spasmogenic properties of a stable thromboxane mimic, U46619, were determined in the isolated rat aorta after 1, 4, 8, or 12 hr of acute ethanol exposure in vitro or after 12 days of chronic exposure by inhalation. Acute ethanol exposure (87–822 m m ) increased the baseline tension of aortic rings in a concentration‐dependent manner. Moderate concentrations of ethanol (11 and 43 m m ) decreased the maximum tensile response of rat aortic rings to U46619 after 8 and 4 hr of exposure, respectively. In contrast, higher ethanol concentrations (87 and 411 m m ) did not significantly effect the maximum tensile response to U46619. Ethanol at 822 vm completely inhibited the response to U46619 and this inhibition could be 85% reversed after removal of ethanol. The inhibitory effect of 1.64 Methanol was irreversible.