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Genetic Variants of Enzymes of Alcohol and Aldehyde Metabolism
Author(s) -
Holmes Roger S.
Publication year - 1985
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1985.tb05599.x
Subject(s) - enzyme , alcohol , aldehyde dehydrogenase , metabolism , aldehyde , ethanol metabolism , biochemistry , chemistry , biology , genetics , catalysis
The distribution of genetic variants (or gene markers) for alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde oxidase, and aldehyde reductase isozymes has been examined among 12 inbred strains of mice. Electrophoretic variants are described for the major liver and stomach alcohol dehydrogenase isozymes (ADH‐A 2 and C 2 ); liver, kidney, and stomach aldehyde dehydrogenase isozymes (AHD‐1; AHD‐2; AHD‐4); a liver‐specific aldehyde reductase (AHR‐A 2 ); and a liver aldehyde oxidase isozyme (AOX‐2). Genetically determined activity variants were observed for a testis‐specific aldehyde dehydrogenase (AHD‐6); liver and kidney aldehyde reductase isozymes (AHR‐3 and AHR‐4); and the major aver AOX isozyme (AOX‐1). These variants may serve as useful gene markers in alcohol research involving animal model studies with inbred strains in mice.