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Alcohol and Aldehyde Dehydrogenase Isoenzymes in North American Indians
Author(s) -
Rex Douglas K.,
Bosron William F.,
Smialek John E.,
Li TingKai
Publication year - 1985
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1985.tb05540.x
Subject(s) - aldehyde dehydrogenase , isozyme , alcohol dehydrogenase , phenotype , aldh2 , allele , enzyme , population , biology , allele frequency , biochemistry , genetics , gene , medicine , environmental health
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isoenzyme phenotypes were determined in autopsy liver samples from 50 North American Indians from New Mexico. Forty‐six of the 50 livers had sufficient ADH activity to allow phenotyping at the ADH, and ADH, loci. All 46 livers possessed the “typical” ADH,1–1 phenotype. The frequency of the ADH allele was 0.59 and is the highest thus far reported in any racial population. All 50 livers possessed the ALDH I isoenzyme which exhibits the greatest anodic mobility on starch gel electrophoresis at pH 7.6. The results show that ADH and ALDH phenotypes among American Indians living in New Mexico are very similar to those of Caucasian populations and quite different from those of Orientals.