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Sensitivity of Individual Erythrocyte Membrane Phospholipids to Changes in Fatty Acid Composition in Chronic Alcoholic Patients
Author(s) -
Droitte Philippe La,
Lamboeuf Yves,
Blanquat Georges de Saint,
Bezaury JeanPierre
Publication year - 1985
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1985.tb05536.x
Subject(s) - phosphatidylcholine , linoleic acid , phosphatidylserine , fatty acid , chemistry , biochemistry , phospholipid , ethanol , cholesterol , composition (language) , ingestion , phosphatidylethanolamine , membrane , arachidonic acid , medicine , enzyme , linguistics , philosophy
The erythrocyte membrane levels of total phospholipids and cholesterol and the fatty acid composition of individual groups of phospholipids (phosphatjdylethanolamine, phosphatidylserine plus phospha‐tidylinositol, and phosphatidylcholine) were studied in 10 patients admitted for ethanol detoxification and in 14 control subjects. The fatty acid composition of the patient phospholipids was modified but the level of cholesterol and the level of phospholipids remained unchanged. The fatty acid changes were mainly confined to phosphatidylcholine. The modifications concerned the levels of the oc‐tadecenoic acids (18:1) which rose (p < 0.01), and linoleic acid (18:2) which fell (p < 0.05). These results suggest that chronic ethanol ingestion may perturb the cell membrane organization with, in consequence, possible effects on cell morphology and functions.