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Relationship between γ‐Glutamyl Transpeptidase and Mean Urinary Alcohol Levels in Alcoholics While Drinking and after Alcohol Withdrawal
Author(s) -
Orrego H.,
Blake J. E.,
Israel Y.
Publication year - 1985
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1985.tb05038.x
Subject(s) - abstinence , urinary system , alcohol , alcohol consumption , medicine , alcohol and health , urine , alcohol dependence , alcohol intake , physiology , gastroenterology , psychiatry , chemistry , biochemistry
In 42 patients with alcoholic Hvor disease in whom daily urinary othsnol concentrations wars measured for 3 months, aftar an abstinence of at toast 1 month, ssrum γ‐gfutamyl transpeptidase (GGT) activity was found to corraiata (r = 0.69; p < 0.0001) with moan urinary alcohol levels. Ttia halt‐life of sorum GGT decay in 32 patients who remained abstinent for an 6‐week period was calculated to be 26 days. This prolonged half‐life can result in high serum GGT levels in patients abstinent for prolonged periods, in whom serum GGT baselines before abstinence were very high. Individual variations in serum GGT levels should be interpreted in relation to continued alcohol consumption, keeping in mind the long halMrfe for this enzyme in theee patients.