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Brain and Liver Monoamine Oxidase Type A and Type B Activity in Alcoholics and Controls
Author(s) -
Major Leslie F.,
Hawtey Rollin J.,
Saini Nirmal,
Garrick Nancy A.,
Murphy Dennis L.
Publication year - 1985
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1985.tb05036.x
Subject(s) - monoamine oxidase , serotonin , monoamine oxidase a , monoamine neurotransmitter , monoamine oxidase b , medicine , endocrinology , chemistry , enzyme , biochemistry , receptor
Monoamine oxidase activity in human postmortem brain and liver samples m measured In a group of patients with a prior history of atcoholiam and compared to a control group with no prior history of atcoholiam. liver samples from patients with a prior history of alcoholism showed signtficantly lower monoamine oxidase activity with both phenytethytemine and serotonin as substrates. Postmortem brain samples however, were not different in the two groups