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Diethyldithiocarbamic Acid‐Methyl Ester Distribution, Elimination, and LD 50 in the Rat after Intraperitoneal Administration
Author(s) -
Faiman Morris D.,
Artrnan Linda,
Maziasz Tim
Publication year - 1983
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1983.tb05466.x
Subject(s) - disulfiram , urine , gastrointestinal tract , feces , intraperitoneal injection , toxicity , chemistry , glucuronide , tissue distribution , pharmacology , distribution (mathematics) , kidney , medicine , biochemistry , biology , mathematical analysis , mathematics , paleontology
Following the intraperitoneal administration of S 35 diethyldithiocarbamic acid‐methyl ester (S 35 DDTC‐Me) to male rats, maximal total radioactivity (S 35 ) in most tissues was found 1 hr after dosing. Twelve hr after intraperitoneal S 35 DDTC‐Me, most of the total radioactivity was found in urine. The feces accounted for approximately 15% of the total radioactivity. No radioactivity was detected in the breath. The kidney exhibited the greatest uptake of radioactivity, while the least uptake was found in the brain and heart. Most of the radioactivity in the tissues was due to the inorganic sulfate. S 35 DDTC‐glucuronide was found in the gastrointestinal tract and feces. The LD 50 for DDTC‐Me given intraperitoneally to male rats and mice was 167 and 263 mg/kg, respectively. Symptoms of toxicity proceeding death of the animals resembled those symptoms observed with disulfiram toxicity.