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Influence of Ethanol on Reproductive Functions of the Adult Male Rat as a Function of Body Weight
Author(s) -
Rivier Catherine,
Vale Wylie
Publication year - 1983
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1983.tb05443.x
Subject(s) - testosterone (patch) , body weight , ethanol , endocrinology , alcohol , medicine , adult male , androgen , reproduction , chemistry , biology , physiology , andrology , hormone , biochemistry , ecology
Adult male rats were exposed to alcohol vapors for 3–4 weeks. Blood alcohol levels (BAL) ranged from 90 to 190 mg/100 ml. BAL of ≥ 0–130 mg/100 ml were compatible with adequate body weight gains and were not associated with diminished plasma testosterone (T) levels or reduced sex organ weights. BAL ≥ 180 mg/100 ml were associated with inhibition of androgen secretion only in those anlmals who failed to grow. From these results we conclude that in growing animals, the medium term exposure to ETOH leads to inhibition of reproductive parameters when high BALs induce weight loss, but not when adequate body growth is maintained.