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The Metabolic Fate of Double‐Labeled Disulfiram
Author(s) -
Neiderhiser Dewey H.,
Wych Gregory,
Fuller Richard K.
Publication year - 1983
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1983.tb05439.x
Subject(s) - disulfiram , urine , expired air , excretion , feces , stomach tube , chemistry , pharmacology , stomach , dosing , metabolism , chromatography , medicine , biology , biochemistry , microbiology and biotechnology , anatomy
The metabolic fate of disulfiram labeled with both 14 C and 35 S was studied in the rat. After administration of 50 mg of 14 C, 35 S‐disulfiram dissolved in corn oil to rats by stomach tube, 95% of the radioactivity was recovered in urine, feces, and expired air at 144 hr. The major portion of the excreted radioactivity was in urine (75 ± 6%). Feces and expired air contained 13 ± 2% and 6 ± 5% of the dose, respectively. No measurable radioactivity was found in the body organs or carcass. Pretreatment of rats with unlabeled disulfiram for 20 days prior to administration of 14 C, 35 S‐disulfiram led to more rapid catabolism of the drug and more rapid excretion of radioactivity in the urine during the first 12 hr after dosing.