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Acute Ethanol Treatment Modifies Response Properties and Habituation of the DR‐VR Reflex in the Isolated Frog Spinal Cord
Author(s) -
Rinaldi P. C.,
Nishimura L. Y.,
Thompson R. F.
Publication year - 1983
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1983.tb05438.x
Subject(s) - habituation , spinal cord , reflex , ethanol , neuroscience , stimulation , dorsum , chemistry , anatomy , anesthesia , psychology , medicine , biochemistry
Ethanol modification of habituation, a fundamental form of behavioral plasticity, was examined in the isolated frog spinal cord preparation. The polysynaptic dorsal root to ventral root (DR‐VR) reflex response was assessed in normal Ringer's and at one of four ethanol concentrations. The reflex itself was facllitated at lower levels (0.025%) and depressed at higher levels (0.05–0.5%) Of ethanol. Habituation, decrement of the polysynaptic ventral root response to repeated dorsal root stimulatlon, was reduced at all ethanol concentrations. Understanding the mechanisms of ethanol action involved in the disruptlon of simple forms of plasticity will help us to explain Its actions on more complex forms of associa‐tional processes.