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Aromatization of Androstenedione by Microsomes from the Human Placenta after Gestational Alcohol Consumption
Author(s) -
Sheean Leon A.
Publication year - 1983
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1983.tb05419.x
Subject(s) - androstenedione , aromatization , microsome , human placenta , alcohol , ethanol , chemistry , alcohol consumption , endocrinology , medicine , placenta , michaelis–menten kinetics , biochemistry , enzyme , gestational age , pregnancy , fetus , biology , enzyme assay , catalysis , hormone , androgen , genetics
Human placental microsomes were used to evaluate rates of andre stenedione aromatiration from patients selected for gestational alcohol consumption. After term delivery, kinetic comparisons of specific activity and Michaelis constants of reduced pyridine nucleotide cotactors were determined. The data failed to indicate a significant alcohol effect on these enzymatic parameters.