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Piracetam Reduces Alcohol Withdrawal in Mice without Potentiating Alcohol Sedative Effects
Author(s) -
Serby Michael,
Segamick David J.,
Cordasco Donna Mandio,
Rotrosen John
Publication year - 1982
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1982.tb05016.x
Subject(s) - piracetam , sedative , pharmacology , ethanol , alcohol , mechanism of action , medicine , anesthesia , chemistry , biochemistry , in vitro
Piracetam reduced the intensity of withdrawal behavior in mice that had been exposed to ethanol for 4 days. However, in contrast to other antiwithdrawal agents, piracetam did not potentiate the sedative effects of acute ethanol administration. While the mechanism of action of piracetam is unknown, these findings suggest that piracetam elicits its antiwithdrawal effects by a mechanism differing from that of other agents.