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Tolerance to Ethanol Hypothermia in Inbred Mice: Genotypic Correlations with Behavioral Responses
Author(s) -
Crabbe John C.,
Janowsky Jeri S.,
Young Emmett R.,
Kosobud Ann,
Stack Julianne,
Rigter Henk
Publication year - 1982
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1982.tb05007.x
Subject(s) - hypothermia , ethanol , ataxia , inbred strain , drug tolerance , anesthesia , cross tolerance , medicine , biology , endocrinology , pharmacology , biochemistry , gene , neuroscience , morphine
Hypothermia was studied 5 min before, and 30 and 60 min after intraperitoneal administration of ethanol (3 g/kg) in 20 inbred strains of mice. Ethanol was given daily for 8 days, and temperatures were taken on Days 1, 3, 5, and 8. Tolerance was indexed by the reduction in hypothermia over days. There were large strain differences in baseline temperature, the hypothermic effect of ethanol, and in development of tolerance to hypothermia. Some strains of mice (DBA/1J, DBA/2N, MA/MyJ, and PL/J) did not develop tolerance to the hypothermic effect of ethanol. Initial sensitivity to the hypothermic effect of ethanol was significantly genetically correlated with tolerance development, indicating control of these responses by common genes. Ethanol‐induced changes in activity and ataxia, as well as blood ethanol concentrations, were also assessed. Although there were significant strain differences in activity reduction, ataxia, blood‐ethanol concentrations, and changes in these parameters during the course of chronic treatment, none of these variables could explain the genetic differences in hypothermic sensitivity and tolerance .