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Acetaldehyde Adducts of Phospholipids
Author(s) -
Kenney William C.
Publication year - 1982
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1982.tb05000.x
Subject(s) - acetaldehyde , chemistry , phosphatidylethanolamine , phosphatidylserine , microsome , membrane , adduct , borohydride , covalent bond , biochemistry , enzyme , organic chemistry , phospholipid , phosphatidylcholine , ethanol , catalysis
Incubation of rat liver microsomes with acetaldehyde followed by reduction with borohydride of the Schiff bases formed leads to the formation of the N ‐ethyl derivatives of phosphatidylethanolamine and phosphatidylserine. Proof for this structure came from a comparison of these microsomal derivatives, and the nitrogenous bases derived therefrom by acid hydrolyses, with synthetic N ‐ethylphosphatidytethanolamine, N ‐ethylphosphatidylserine, N ‐ethylethanolamine, and N ‐ethylserine. Modification of membrane phospholipids by covalent binding of acetaldehyde to form Schiff bases may perturb some of the biochemical processes associated with membranes.