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The In Vivo Metabolism of Tertiary Butanol by Adult Rats
Author(s) -
Baker Rodney C.,
Sorensen Stephen M.,
Deitrich Richard A.
Publication year - 1982
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1982.tb04970.x
Subject(s) - butanol , in vivo , metabolism , acetone , chemistry , ethanol , alcohol , n butanol , in vitro , biochemistry , tertiary alcohols , chromatography , biology , microbiology and biotechnology
The metabolism of tertiary butanol has been considered to be limited to direct conjugation of the hydroxyl group. Therefore, the alcohol has been used to differentiate between the direct effects of ethanol and those caused by metabolism or metabolic products of ethanol. The in vitro oxidation of tertiary butanol has been reported, and in this report we describe the in vivo oxidation of tertiary butanol. Radiolabeled and stable isotope‐labeled acetone was recovered from animals treated with corresponding labeled t‐butanol. 14 CO 2 was also recovered from animals treated with [ 14 C]t‐butanol.