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The Effect of Chronic Poisoning with Carbon Tetrachloride on Voluntary Consumption of Ethanol by Mice
Author(s) -
Dole Vincent P.,
Gentry R. Thomas,
Ho Ann
Publication year - 1981
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1981.tb05363.x
Subject(s) - hepatotoxin , ethanol , carbon tetrachloride , turnover , appetite , alcohol , medicine , saline , chemistry , toxicology , physiology , zoology , endocrinology , toxicity , biochemistry , biology , management , organic chemistry , economics
Mice were chronically poisoned with carbon tetrachloride injected twice weekly, intraperftoneally, in doses of 0.05‐0.80 mg/g over 10 to 16 weeks. The poisoned animals, as compared to vehicle‐injected controls, showed marginally significant increases in voluntary consumption of ethanol in a three‐bottle choice (water, 10% and 20% ethanol continuously available), but not to a degree that could be considered alcoholic. The average daily intakes of ethanol remained within the range of variation for normal animals of this strain; there was no consistent shift in preference from 10% to 20% ethanol, and the distribution of drinking times within the 24‐hour cycle remained normal. The relevance of these findings to the clinical problem of alcoholism is that the appetite for alcohol, a potential hepatotoxin, persists despite serious damage to the liver.