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MembraneiBuffer Partition Coefficient for Ethanol in Dimyristoylphosphatidylcholine
Author(s) -
Rowe Elizabeth S.
Publication year - 1981
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1981.tb04899.x
Subject(s) - partition coefficient , chemistry , solvent , aqueous solution , thermodynamics , phase transition , ethanol , phase (matter) , analytical chemistry (journal) , chromatography , organic chemistry , physics
Phase transitions of dimyristoylphosphatidylcholine (DMPC) are followed using optical density measurements, as a function of aqueous ethanol concentration. The shift of the phase transition to lower temperatures is interpreted in terms of the thermodynamics of freezing point depressions. This analysis provides a partition coefficient of ethanol into DMPC of 0.07 liter of solution/kg membrane or 2.64 moles of solvent/mole of DMPC.