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Effect of Ethanol on Formation of Bile
Author(s) -
Strasberg S. M.
Publication year - 1981
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1981.tb04874.x
Subject(s) - secretion , ethanol , medicine , chemistry , bile acid , endocrinology , biochemistry
The effects of ethanol on bile formation have been studied in the rat, dog, and man, in both acute and chronic models. The acute and chronic effects differ. Given acutely, ethanol suppresses bile flow and bile acid secretion rate. Chronic administration appears to increase both components of canalicular flow and bile acid secretion rate. Intestinal and hepatic actions are probably involved in the latter effect. Secretion of other biliary lipids and diagnostic anions are also reduced by ethanol.