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Brain Aldehyde Dehydrogenase in Human Alcoholics and Controls
Author(s) -
Pietruszko Regina,
Reed Donna M.,
Vallari Robert C.,
Major L. Franklin,
Saini Nirmal,
Hawley Rollin J.
Publication year - 1981
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1981.tb04869.x
Subject(s) - aldehyde dehydrogenase , human brain , aldehyde , aldh2 , enzyme , temporal lobe , medicine , isozyme , brain cancer , cancer , endocrinology , biochemistry , chemistry , psychiatry , epilepsy , catalysis
Human postmortem brain samples from temporal lobe of 23 alcoholics and 19 controls (13 with cancer and six without cancer) were used for determination of low Km (micromolar) and high Km (millimolar) aldehyde dehydrogenase activity. Despite histories of severe alcoholism leading to death through multiple complications, the mean values for either low or high Km activity did not differ significantly from that of controls similarly studied.