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Disulfiram‐Associated Hypercholesterolemia
Author(s) -
Rogers Elizabeth L.,
Naseem Syed M.
Publication year - 1981
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1981.tb04868.x
Subject(s) - disulfiram , limiting , cholesterol , pharmacology , hmg coa reductase , mechanism of action , reductase , drug , chemistry , total cholesterol , medicine , endocrinology , biochemistry , enzyme , mechanical engineering , in vitro , engineering
The rat model is used to verify disulfiram‐associated hypercholesterolemia and to determine a mechanism of action. Administration of disulfiram 15 mg/kg/day for 3 wk is associated with a 25% increase in serum cholesterol which is reversible with discontinuance of the drug. The hypercholesterolemia is due in part to a fourfold increase in activity of hepatic HMG‐CoA reductase, the rate‐limiting step in cholesterol biosyntheses.