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Plasma Glutamate Dehydrogenase: Clinical Application in Patients With Alcoholic Liver Disease
Author(s) -
Worner T. M.,
Lieber C. S.
Publication year - 1980
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1980.tb04845.x
Subject(s) - glutamate dehydrogenase , alcoholic liver disease , glutamate receptor , detoxification (alternative medicine) , medicine , ethanol , alcohol dehydrogenase , gastroenterology , liver biopsy , lactate dehydrogenase , liver disease , anesthesia , endocrinology , biopsy , pathology , enzyme , chemistry , biochemistry , cirrhosis , receptor , alternative medicine
The time course of plasma glutamate dehydrogenase (GDH) elevation was studied in 42 male alcoholics admitted for alcohol detoxification or for the treatment of medical complications of alcoholism and in 2 volunteers consuming 2 g/kg/day of ethanol under metabolic ward conditions. GDH values were usually highest during or immediately after cessation of drinking; thereafter, they fell rapidly toward the normal range. Early GDH values correlated well with liver histology in 37 patients who subsequently underwent diagnostic liver biopsy.