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The Effect of Alcohol on Dopamine Metabolism in the Caudate Nucleus of an Unanesthetized Monkey
Author(s) -
Weiner H.,
Myers R. D.,
Simpson C. W.,
Thurman J. A.
Publication year - 1980
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1980.tb04844.x
Subject(s) - caudate nucleus , dopamine , primate , metabolism , perfusion , ethanol , chemistry , medicine , alcohol , endocrinology , anesthesia , biology , neuroscience , biochemistry
Previously it was shown that the acute administration of ethanol to the rat significantly alters the metabolism of the dopamine (DA) in liver but not in brain tissue. To extend this finding to the primate, two push‐pull perfusion cannulas were implanted in the regions of the left and right caudate nucleus of a Macaca nemistrina. After 14 C‐DA was injected into the caudate, the site was perfused with an artificial CSF and the perfusate analyzed for the major metalolites of DA. Ethanol was then administered in a dose of 6 g/kg by the nasopharyngeal route. The results show that very little alteration occurs in the metabolism of DA during or postethanol intoxication.