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Biochemical Evidence for an Interaction of Ethanol and Stress: Preliminary Studies
Author(s) -
Pohorecky L. A.,
Rassi E.,
Weiss J. M.,
Michalak V.
Publication year - 1980
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1980.tb04843.x
Subject(s) - ethanol , saline , corticosterone , endocrinology , medicine , chemistry , stress (linguistics) , biochemistry , hormone , linguistics , philosophy
Studies were carried out to examine the interaction of stress and ethanol. Ethanol (0.5 g/kg)‐treated, stressed (electric foot shocks) rats exhibited less marked elevations in plasma levels of nonesterified fatty acids and of corticosterone compared to saline‐treated stressed subjects. Stress alone markedly elevated these two parameters in plasma. Ethanol treatment alone also resulted in small elevations in both parameters. Results provide support for a significant interaction of ethanol and stress, and might provide some basis for the purported stress‐relieving effect of low doses of ethanol.