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Disulfiram Distribution and Elimination in the Rat After Oral and Intraperitoneal Administration
Author(s) -
Faiman Morris D.,
Artman Linda,
Haya Katsuji
Publication year - 1980
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1980.tb04841.x
Subject(s) - disulfiram , gastrointestinal tract , oral administration , kidney , pharmacology , distribution (mathematics) , chemistry , intraperitoneal injection , glucuronide , pancreas , feces , tissue distribution , route of administration , medicine , urine , endocrinology , biology , mathematical analysis , mathematics , paleontology
35 S disulfiram (DSF), 7 mg/kg, was administered as a single dose to rats both orally (p.o.) or intraperitoneally (i.p.). The 35 S DSF was rapidly absorbed by either route. Kidney, pancreas, liver, and the gastrointestinal tract exhibited the greatest uptake of radioactivity, while the least was found in brain. Preferential tissue uptake was similar with both routes of administration. Seven percent of the dose was excreted in the feces. Approximately 12% of the dose was eliminated by the breath as CS 2 . The 35 S‐DSF was rapidly metabolized to the 35 S‐diethyldi‐thiocarbamate‐glucuronide and 3B S inorganic sulfate. Approximately 93% of the radioactivity was accounted for 48 hr after p.o. or i.p. 35 S administration.