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Antagonism of Ethanol Narcosis in Mice by Hyperbaric Pressures of 4–8 Atmospheres
Author(s) -
Alkana Ronald L.,
Malcolm Richard D.
Publication year - 1980
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1980.tb04830.x
Subject(s) - antagonism , ethanol , oxygen , hyperbaric oxygen , chemistry , anesthesia , pharmacology , medicine , biochemistry , organic chemistry , receptor
Hyperbaric treatment with 100% oxygen or oxygen‐helium mixtures at 4–8 atmospheres absolute significantly reduced ethanol sleep‐time and increased wake‐up blood ethanol concentrations in C57 mice. The results indicate that the antagonsim does not result from direct effects of oxygen nor from enhanced ethanol elimination, but appears to involve a direct effect of hyper‐baric treatment.