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Cupro‐Zinc Superoxide Dismutase:A Possible Biologic Marker for Alcoholism (Studies in Black Patients)
Author(s) -
Villano Bert C. Del,
Tischfield J. A.,
Schacter Lee P.,
Stilwil David,
Miller Sheldon I.
Publication year - 1979
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1979.tb05325.x
Subject(s) - superoxide dismutase , zinc , chronic alcoholism , medicine , immunology , chemistry , oxidative stress , organic chemistry
Cupro‐zinc superoxide dismutase (SOD‐1) was measured by competition radioimmune assay of erythrocyte lysates of alcoholic and control subjects. Normal amounts of SOD‐1 were found in the extract from control subjects (815 ng/mg Hb) and from white alcoholics (874 ng/mg Hb). However, the level of SOD‐1 in lysates from black alcoholics (1033 ng/mg Hb) was significantly increased ( p = 0.0001, rank‐sum test) compared with black and white controls. This increase was not related to any other observed hematologic disorder or to any historical, demographic, or laboratory value examined.