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The Photochemical Action Spectrum of the Microsomal Ethanol Oxidizing System
Author(s) -
Fabry Thomas L.,
Lieber Charles S.
Publication year - 1979
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1979.tb05303.x
Subject(s) - oxidizing agent , ethanol , action spectrum , carbon monoxide , photochemistry , chemistry , microsome , cytochrome , wavelength , absorption (acoustics) , visible spectrum , absorption spectroscopy , materials science , organic chemistry , optics , enzyme , catalysis , optoelectronics , physics , composite material
The inhibition of the microsomal ethanol oxidizing system (MEOS) by carbon monoxide (CO) can be reversed by illumination with lights of differing wavelengths. The authors determined the efficiency of this reversal as a function of the illuminating light. Maximum efficiency was obtained in the wavelength band around440–450 nm, which is near the absorption of the reduced cytochrome‐P‐450‐carbon monoxide complex. When the experiment was repeated with microsomes prepared from ethanol‐fed rats, the wavelength for maximum efficiency shifted towards higher values