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Effect of an Acute Dose of Ethanol on Rat Liver Microsomal Mixed Function Oxygenase Components and Membrane Lipid Composition
Author(s) -
Pennington Sam N.,
Smith Carlton P.,
Tapscott Edward B.
Publication year - 1978
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1978.tb05819.x
Subject(s) - microsome , ethanol , glycerol , chemistry , microsoma , medicine , endocrinology , oxidase test , cytochrome , composition (language) , oxygenase , mixed function oxidase , biochemistry , enzyme , biology , linguistics , philosophy
The lipid composition of rat liver microsomes was not altered in response to a single acute dose of ethanol relative to isocaloric glycerol‐treated controls. Microsomal cytochrome P‐450 was transiently elevated, the elevation paralleling blood ethanol levels. Microsomal NADPH oxidase was transiently elevated relative to the activity in isocaloric glycerol‐treated controls.