Premium
Ethanol Increases Rate of Isolated Atria
Author(s) -
Lake David A.,
Chilian William M.,
Roberts Lou Anne
Publication year - 1978
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1978.tb05811.x
Subject(s) - chronotropic , ethanol , inotrope , acetaldehyde , acetylcholine , chemistry , contraction (grammar) , medicine , endocrinology , heart rate , pharmacology , biochemistry , blood pressure
Ethanol has a positive chronotropic and negative inotropic effect on isolated spontaneously beating rabbit atria. Both effects increased with increasing ethanol concentrations in the bathing medium. This response is apparently a direct action of ethanol on the myocardium and is not due to the release of catecholamines, acetylcholine, or acetaldehyde produced by the oxidative metabolism of ethanol. Ethanol is one of the few pharmacologic agents having opposite actions on heart rate and force of contraction.