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Potentiation of Lithium Toxicity by Ethanol in Rats and Mice
Author(s) -
Ho Andrew K. S.,
Ho C. C.
Publication year - 1978
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1978.tb04749.x
Subject(s) - lithium (medication) , ethanol , long term potentiation , toxicity , chemistry , pharmacology , acute toxicity , urine , lithium chloride , excretion , medicine , biochemistry , organic chemistry , receptor
The effects of ethanol treatments, both acute (single, intraperitoneal) and chronic (forced drinking of ethanol for 10 mo), on the distribution, excretion of lithium and urine output were studied in rats. Retention of lithium induced by ethanol appeared to be responsible for the potentiation of lithium toxicity. The potential hazard in the interaction between lithium and ethanol is discussed.