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The Persistence of the Alcohol‐Disulfiram Reaction After Discontinuation of Drug in Patients With and Without Liver Disease
Author(s) -
Iber Frank L.,
Chowdhury Bhanwarial
Publication year - 1977
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1977.tb05795.x
Subject(s) - disulfiram , discontinuation , drug , medicine , ethanol , alcohol , liver disease , persistence (discontinuity) , gastroenterology , disease , pharmacology , anesthesia , chemistry , biochemistry , geotechnical engineering , organic chemistry , engineering
Fifty‐two normals and 15 patients with liver disease were studied with a 5‐g challenge dose of ethanol at various intervals after stopping disulfiram 24 hr previously. The reaction to disulfiram and ethanol does not persist beyond 24 hr in normal patients, but in patients with abnormal liver function, it may continue for as long as 96 hr.