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Excretion of Radioactivity Following the Administration of 35 Sulfur‐Labeled Disulfiram in Man
Author(s) -
Iber Frank L.,
Dutta Sudhir,
Shamszad Mahin,
Krause Sandra
Publication year - 1977
Publication title -
alcoholism: clinical and experimental research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.267
H-Index - 153
eISSN - 1530-0277
pISSN - 0145-6008
DOI - 10.1111/j.1530-0277.1977.tb05794.x
Subject(s) - disulfiram , excretion , urine , chemistry , ingestion , sulfur , radiochemistry , carbon 14 , pharmacology , biochemistry , medicine , organic chemistry , physics , quantum mechanics
Following ingestion, disulfiram is rapidly excreted in the urine and breath, with 90% of the dose gone in 3 days. In some subjects, the enzymes in the liver that oxidized diethyldithiocarbamate to carbon disulfide are very active, making this the principal metabolic pathway. However, if this pathway is not active, there is an increased excretion of DDC into the urine.